FILE - This May 16, 2011 photo shows Timothy Ray Brown with his dog, Jack, on Treasure Island in San Francisco. Brown, who was known for years as the Berlin patient, had a transplant in Germany from a donor with natural resistance to the AIDS virus. It was thought to have cured Brown’s leukemia and HIV. But in an interview Thursday, Sept. 24, 2020, Brown said his cancer returned last year and has spread widely. His case has inspired scientists to seek more practical ways to try to cure the disease. (AP Photo/Eric Risberg)

FILE - This May 16, 2011 photo shows Timothy Ray Brown with his dog, Jack, on Treasure Island in San Francisco. Brown, who was known for years as the Berlin patient, had a transplant in Germany from a donor with natural resistance to the AIDS virus. It was thought to have cured Brown’s leukemia and HIV. But in an interview Thursday, Sept. 24, 2020, Brown said his cancer returned last year and has spread widely. His case has inspired scientists to seek more practical ways to try to cure the disease. (AP Photo/Eric Risberg)

First man cured of HIV infection now has terminal cancer

Brown’s first transplant in 2007 was followed by a second in 2008

Timothy Ray Brown, the first person known to have been cured of HIV infection, says he is now terminally ill from a recurrence of the cancer that prompted his historic treatment 12 years ago.

Brown, dubbed “the Berlin patient” because of where he lived at the time, had a transplant from a donor with a rare, natural resistance to the AIDS virus. For years, that was thought to have cured his leukemia and his HIV infection, and he still shows no signs of HIV.

But in an interview with The Associated Press, Brown said his cancer returned last year and has spread widely. He’s receiving hospice care where he now lives in Palm Springs, California.

“I’m still glad that I had it,” Brown said of his transplant.

“It opened up doors that weren’t there before” and inspired scientists to work harder to find a cure, which many had begun to think was not possible, the 54-year-old said Thursday.

“Timothy proved that HIV can be cured, but that’s not what inspires me about him,” said Dr. Steven Deeks, an AIDS specialist at the University of California, San Francisco, who has worked with Brown to further research toward a cure.

“We took pieces of his gut, we took pieces of his lymph nodes. Every time he was asked to do something, he showed up with amazing grace,” Deeks said.

Brown was an American working as a translator in Berlin in the 1990s when he learned he had HIV. In 2006, he was diagnosed with leukemia.

Dr. Gero Huetter, a blood cancer expert at the University of Berlin, believed that a marrow transplant was Brown’s best chance of beating the leukemia. He wondered, could he also cure Brown’s other life-threatening disease by using a donor with a gene mutation that provides natural resistance to the AIDS virus?

Donors like these are very rare and transplants are risky. Doctors have to destroy the patient’s diseased immune system with chemotherapy and radiation, then transplant the donor’s cells and hope they develop into a new immune system for the recipient.

Brown’s first transplant in 2007 was only partly successful: His HIV seemed to be gone but his leukemia was not. He had a second transplant from the same donor in March 2008 and that one seemed to work.

Since then, Brown has repeatedly tested negative for HIV and has frequently appeared at AIDS conferences where cure research is discussed.

“He’s been like an ambassador of hope,” said Brown’s partner, Tim Hoeffgen.

A second man, Adam Castillejo — called “the London patient” until he revealed his identity earlier this year — also is believed to have been cured by a transplant similar to Brown’s in 2016.

But donors like these are scarce and the procedure is too risky to be widely used.

Scientists have been testing gene therapy and other ways to try to get the effect of the favourable gene mutation without having to do a transplant. At an AIDS conference in July, researchers said they may have achieved a long-term remission in a Brazil man by using a powerful combination of drugs meant to flush dormant HIV from his body.

Mark King, a Baltimore man who writes a blog for people with HIV, said he spoke with Brown earlier this week and is grateful for what Brown has contributed to AIDS research.

“It is unfathomable what value he has been to the world as a subject of science. And yet this is also a human being who is a kind, humble guy who certainly never asked for the spotlight,” King said. “I think the world of him.”

Marilynn Marchione, The Associated Press

Like us on Facebook and follow us on Twitter.

Want to support local journalism? Make a donation here.

HIV/AIDS

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Interior Health reported 79 new cases of COVID-19 and two new death in the region Friday, Jan. 22, 2021. (Ben Hohenstatt/Juneau Empire)
79 new COVID-19 cases, two deaths reported in Interior Health

Both of Friday’s deaths were both recorded at long-term care homes

(File photo)
Interior Health declares COVID-19 outbreak at Teck’s Elk Valley operations over

48 cases were linked to three Teck locations in the Elk Valley

(File photo)
Sparwood backs calls to declare Canadian overdose crisis a national public health emergency

Paramedics across B.C. responded to more overdose calls in 2020 than ever before

The district of Sparwood is seeking feedback on its Recreation Master Plan. (Scott Tibballs / The Free Press)
Non-medical cannabis store proposed for Sparwood

If approved, Elk Valley Cannabis would be the first cannabis business in the district

Natalie Joynes, Theo Hepher, Kai Dedey, and Sophia Becker sit on a blanket enjoying FYAN’s summer youth programming. (Soranne Floarea/ The Free Press)
Job Readiness Workshops available for local youth

Registration is now open for the series of free virtual workshops

Toronto Public Health nurse Lalaine Agarin sets up for mass vaccination clinic in Toronto, Jan. 17, 2021. B.C. is set to to begin its large-scale immunization program for the general public starting in April. THE CANADIAN PRESS/Frank Gunn
B.C.’s COVID-19 mass vaccinations expected to start in April

Clinics to immunize four million people by September

Sunnybank in Oliver. (Google Maps)
Sunnybank long-term care in Oliver reports third COVID-19 death

The facility currently has an outbreak with 35 cases attached to it

Chief Public Health Officer Theresa Tam speaks during a daily briefing in Ottawa. (THE CANADIAN PRESS/Adrian Wyld)
31 cases of COVID-19 variants detected in Canada: Health officials

Dr. Theresa Tam made announces 13 more variant COVID-19 cases in Canada

Royal Inland Hospital in Kamloops. (Dave Eagles/Kamloops This Week file photo)
COVID-19 outbreak declared at Kamloops’ Royal Inland Hospital surgical unit

Despite 6 South being a surgical unit, RIH said surgeries are continuing at the hospital

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

Daily COVID-19 cases reported to each B.C. health region, to Jan. 20, 2021. Island Health in blue, Northern Health green, Interior Health orange, Vancouver Coastal in red and Fraser Health in purple. (B.C. Centre for Disease Control)
B.C.’s COVID-19 infection rate stays stable with 508 cases Friday

Vaccine delivered to more than 110,000 high-risk people

Volunteer firefighters from Grand Forks Fire/Rescue head towards the scene of fatal car crash near Gibbs Creek Road, below Highway 3, Thursday evening, Jan. 21. Photo: Laurie Tritschler
Motorist dies in Highway 3 crash west of Grand Forks

City first responders were called to the scene Thursday evening, Jan. 21

Vancouver Giants defenceman Bowen Byram could be playing for Colorado when the NHL resumes play. (Rik Fedyck/file)
Cranbrook product Bowen Byram makes NHL debut with Avalanche

Highly touted prospect marks first pro game following World Junior tournament in Alberta

The District of Saanich’s communications team decided to take part in a viral trend on Thursday and photoshopped U.S. Senator Bernie Sanders into a staff meeting photo. (District of Saanich/Twitter)
Bernie Sanders makes guest appearance municipal staff meeting in B.C.

Vancouver Island firefighters jump on viral trend of photoshopped U.S. senator

Most Read