Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Dylan Dyke, a 12-year-old boy with autism, spends time with his ducks, Nibbles, left, and Bill, outside his home in Michigan on Aug. 2, 2018. (Cory Morse/The Grand Rapids Press via AP)

Infants should be tested for autism if older siblings are diagnosed, Canadian study suggests

Blood test for infants with sibling who’s been diagnosed would get information to families earlier

Canadian researchers have led a study suggesting infants be tested for autism spectrum disorder before symptoms appear if an older sibling has already been diagnosed with the neurobiological condition.

The odds of a younger sibling having autism are up to 20 per cent, but most children miss out on early intervention for challenges in behaviour and communication because they’re often not diagnosed until age four, previous studies have shown.

Research by Dr. Stephen Scherer, senior scientist and director of the Centre for Applied Genomics at the Hospital for Sick Children in Toronto, and Dr. Lonnie Zwaigenbaum, a professor of pediatrics at the University of Alberta, found a standard blood test analyzing the DNA of infants with a sibling who’s been diagnosed with autism would provide earlier information for families.

The findings were published Thursday in the journal Nature Communications.

They involve 288 infant siblings from Canada and the United States showing that by age three, 157 of the children were either diagnosed with autism spectrum disorder or developing atypically. Of the 157 children, seven per cent were carrying a gene that put them at a very high risk of developing autism.

RELATED: New study suggests autism overdiagnosed, Canadian expert says

Of the seven per cent of kids, 50 per cent were diagnosed with autism by age three and an additional 35 per cent had other developmental challenges.

Scherer said families of autistic children are often concerned about whether a sibling could also be at risk.

“It’s the number one question families have and no one’s ever wrapped any statistics around that and that’s what we present for the first time, with this paper,” he said.

Further genetic testing looking at the entire genome, beyond a blood test called microarray analysis, is being conducted with all the families in the study in hopes it will provide more information about the risk of autism, Scherer said.

The participants were part of the Baby Siblings Research Consortium, which includes independent research groups in Canada, the United States and Europe, though this study included 10 sites in North America, four of them in Canada, Zwaigenbaum said of the testing that is part of an ongoing decade-long research project looking at behavioural predictors of autism.

“Based on the findings of the study, we’re suggesting that the test be focused on younger siblings,” he said. “It could be informative at a time where we’re not likely to see any behavioural signs. So it provides an option for presymptomatic testing to identify infants at highest risk.”

READ MORE: Autism support dog refused bus access for being a ‘pet’

Families who are informed about a younger child’s risk of autism could initiate strategies to help them develop early communication skills before assessment of behaviour by a specialist and intervention by a therapist as part of a cost-effective approach to care, Zwaigenbaum said.

“I think we may be moving to an exciting new time where both biomarkers and developmental surveillance can provide complementary information to help us identify infants at risk.”

Camille Bains, The Canadian Press

Like us on Facebook and follow us on Twitter

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

People are shown at a COVID-19 vaccination site in Montreal, Sunday, April 18, 2021, as the COVID-19 pandemic continues in Canada and around the world. THE CANADIAN PRESS/Graham Hughes
211 new COVID-19 cases in Interior Health over the weekend

Currently, there are 875 active cases of the virus in the region

A nurse prepares a dose of the COVID-19 vaccine in Kelowna on Tuesday, March 16. As of April 19, more than 230,000 doses have been administered across the Interior Health region. (Phil McLachlan/Black Press)
More than 230K doses of COVID-19 vaccine administered across Interior Health

A total of 220,216 first doses and 13,775 second doses have been given to residents across the B.C. Interior

Staff and residents from RMV show their appreciation for the volunteers who enrich their lives. From left to right: Shelley Moulton, Darlene Hutchinson, Betty Schanni, Mark Hudock, Victor Myette, Elinor Siska, Melissa Roger, Anita Braconnier. (Scott Tibballs / The Free Press)
‘We can’t wait for you to come back’: Rocky Mountain Village residents show appreciation for volunteers

Volunteers can’t make in-person visits, but that hasn’t stopped them staying in touch

Members of the community garden hosted their first seed swap and fundraiser at the Greenwood Mall in Sparwood on Monday. (Scott Tibballs / The Free Press)
Sparwood Community Garden hosts first seed swap

Work on the garden at Engelmann Spruce Drive will begin soon

Crews and volunteers responded to a four-hectare wildfire on the lower half of the Aqam community lands near Cranbrook on Friday afternoon. Trevor Crawley photo.
Wildfire season gets early start in the East Kootenay

Fire crews, volunteers respond to two local wildfires, while prescribed burns turn weekend skies smoky

Sunday’s storm rocked one of the ferries crossing Kootenay Lake. Photo: Dirk Jonker
VIDEO: Storm makes for wild ferry ride across Kootenay Lake

The video was captured by ferry employee Dirk Jonker

Families of two of three workers killed in a train derailment near Field, B.C., in 2019 have filed lawsuits accusing Canadian Pacific of gross negligence. The derailment sent 99 grain cars and two locomotives off the tracks. THE CANADIAN PRESS/Jeff McIntosh
Families of workers killed in Field train derailment allege negligence in lawsuit

Lawsuits allege the workers weren’t provided a safe work environment

(New Westminster Police)
4 youth arrested after 30-person brawl in New Westminster leaves 1 seriously injured

Police are looking for witnesses who saw the incident take place

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

South Surrey’s Paul Cottrell, who works with the DFO, tows a grey whale out of Semiahmoo Bay Sunday. (Contributed photo)
Dead whale floating near White Rock towed to shore for necropsy

Animal has been dead since at least April 15

Dr. Bonnie Henry gives her daily media briefing regarding Covid-19 for the province of British Columbia in Victoria, B.C, Monday, December 7, 2020. THE CANADIAN PRESS/Jonathan Hayward
Toddler marks youngest British Columbian to die related to COVID-19

Child one of eight people to die from virus this weekend

Chakalaka Bar & Grill remains open in defiance of orders from Island Health to close. (Cole Schisler photo)
B.C. health authority seeks injunction against restaurant defying COVID-19 orders

Chakalaka Bar and Grill plans to continue serving customers without public health compliance

Kimberley's Steve Tersmette has published Waterfall Hikes In Southern British Columbia, documenting 100 of the areas waterfalls.
Pharmacist Barbara Violo arranges all the empty vials of the Oxford-AstraZeneca COVID-19 vaccines that she has provided to customers at the Junction Chemist which is a independent pharmacy during the COVID-19 pandemic in Toronto, on Monday, April 19, 2021. THE CANADIAN PRESS/Nathan Denette
B.C. to open up AstraZeneca vaccines for all people 40+, set up clinics in hot spots

A total of 13 neighbourhoods and communities will receive the AstraZeneca vaccine

Most Read